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Mild, transient fluid retention/edema and joint or muscle pain, each reported more often on MK-677 than placebo in the same trial, linked to elevated GH and IGF-1

Reduced Inflammation

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Benefits • HGF / c-Met activation — studied as a high-affinity potentiator of hepatocyte growth factor signaling (Kd ≈ 65 pM) • Synaptogenesis — investigated for functional dendritic spine formation and synaptic connectivity • Cognitive research — explored in rodent models of Alzheimer’s-like cognitive impairment • Blood-brain barrier permeability — examined for direct CNS access uncommon among peptide-class compounds • Neurotrophic signaling — linked to high-potency neuronal growth assays • Angiotensin IV pathway research — investigated as a structurally optimized angiotensin IV analog Localized Effects with Nasal Spray • Rapid uptake through the nasal mucosa • Direct olfactory and trigeminal nerve pathway access to the central nervous system • Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability • Dihexa’s small size (504.66 Da) supports efficient nasal mucosal absorption • Particularly relevant for Dihexa given its central c-Met / synaptogenic targets in brain tissue • Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness What Researchers Use It For • HGF / c-Met receptor pharmacology and signal transduction studies • Dendritic spine formation and synaptic plasticity research • Long-term potentiation (LTP) and hippocampal slice electrophysiology • Cognitive performance endpoints in aged and AD-model rodents • Comparative neurotrophic activity studies (vs BDNF, NGF, angiotensin IV) • Angiotensin AT4 receptor / IRAP pathway investigations Identity & Specs • Compound: Dihexa • Synonyms: PNB-0408